PGx CIViC Evidence v1 is a pharmacogenomics dataset derived from the Clinical Interpretation of Variants in Cancer (CIViC) knowledgebase, containing curated evidence linking genomic variants to drug responses, resistance mechanisms, and clinical outcomes in oncology. It aggregates expert-reviewed, literature-sourced evidence items associating specific somatic and germline variants with therapeutic relevance across cancer types. This resource supports precision medicine research by providing structured, community-curated variant-drug associations with associated evidence levels and clinical significance ratings.